TOM Armstrong bagged a hat-trick as Saints completed their Engage Super League regular season campaign with a 34-16 win at Quins RL.It was a tale of two halves as they recovered from a 12-4 deficit to finish the year off with a victory.Saints were 12-4 down at half time as Quins punished indiscretions and got a fair slice of luck.Two forward passes and an ankle tap as the hooter went stopped Royce Simmons’ men imposing themselves on a game they’d pretty much created the main chances in.Tom Armstrong put Saints ahead but ill-discipline handed Quins the territory for Karl Pryce to send in Karl Temata and then bag one himself.In the second half, another try went begging as Saints passed up a four on two overlap before Lee Gaskell produced a piece of brilliance to chip through and get the ball down.Armstrong’ second and third sandwiched Scott Hale’s first in Saints’ colours and Louie McCarthy-Scarsbrook scored against his former employers to complete a satisfying day’s work.Saints fielded a full British 17 with 14 of their players coming through the club’s Academy system.Lee Gaskell and Jonny Lomax paired up once again in the half backs whilst Gary Wheeler made his first start since he was injured at Wigan on Good Friday. Scott Moore deputised for James Roby who was rested after playing in all of Saints matches this season.Carl Forster made his debut off the bench.For Quins, the day was all about Rob Purdham and his final appearance for the club before he heads up to Cumbria.After a pretty tepid opening 10 minutes a massive high ball was knocked on by Luke Dorn giving Saints prime position.And they didn’t disappoint, pinging the ball left for Tom Armstrong to get over in the corner.Quins responded on their next attack – a chip to the corner was knocked sideways by Karl Pryce and Karl Temata charged to the line. Gale converting to make it 6-4.Saints should have taken the lead moments later when Gary Wheeler sidestepped the defence to send in Tom Armstrong, but the winger’s pass was too strong for Paul Wellens to take in.And on 28 minutes Quins forged further ahead after weathering more Saints pressure. This time the ball was kept alive and Karl Pryce increased the lead – following a wonder tackle on Andy Ellis to quell the original attack.Tom Armstrong had a second chalked off for a forward pass as the half entered its final stages and Wellens took a massive bomb.Saints could have scored as the hooter went as Wheeler broke from within his half, but Lee Gaskell was just caught a couple of feet from the line.Saints forced a drop out in the opening ten minutes of the second half and then finally made the pressure pay.After banging on the door, Lee Gaskell chipped ahead and with the Quins defence standing still he touched down – Makinson with the conversion.Within minutes Saints were ahead – a sweeping move again involving Wellens and Wheeler which Armstrong converted.Makinson adding the extras off the touchline.Scott Hale burrowed over for his first in Saints colours before Tom Armstrong finished off a mazy Wellens run.Quins’ pulled one back through Jamie O’Callaghan but Louie McCarthy-Scarsbrook restored the advantage and gave Saints the two points.Match Summary:Quins:Tries: Temata, Pryce, O’CallaghanGoals: Gale (2 from 3)Saints:Tries: Armstrong (3), Makinson, Hale, McCarthy-ScarsbrookGoals: Makinson (5 from 6)Penalties:Quins: 8Saints: 10HT: 4-12FT: 34-16REF: Tim RobyATT: 3546Teams:Quins:1. Luke Dorn; 5. Chris Melling, 2. Jamie O’Callaghan, 31. Karl Pryce, 23. Mark Calderwood; 24. Dan Sarginson, 6. Luke Gale; 17. Danny Ward, 7. Chad Randall, 8. Karl Temata, 12. Chris Bailey, 13. Rob Purdham, 3. Tony Clubb.Subs: 9. Andy Ellis, 10. Oliver Wilkes, 14. Jason Golden, 18. David Williams.Saints:1. Paul Wellens; 28. Tom Makinson, 3. Michael Shenton, 17. Gary Wheeler, 24. Tom Armstrong; 25. Lee Gaskell, 20. Jonny Lomax; 10. James Graham, 14. Scott Moore, 15. Louie McCarthy-Scarsbrook, 12. Jon Wilkin, 18. Matty Ashurst, 16. Paul Clough.Subs: 19. Andrew Dixon, 26. Carl Forster, 27. Nathan Ashe, 29. Scott Hale.
Source:https://www.ucdavis.edu/news/bulldogs%E2%80%99-screw-tails-linked-human-genetic-disease Reviewed by Alina Shrourou, B.Sc. (Editor)Jan 3 2019With their small size, stubby faces and wide-set eyes, bulldogs, French bulldogs and Boston terriers are among the most popular of domestic dog breeds. Now researchers at the University of California, Davis, School of Veterinary Medicine have found the genetic basis for these dogs’ appearance, and linked it to a rare inherited syndrome in humans.Bulldogs, French bulldogs and Boston terriers aren’t the only dogs with short, wide heads, but they do share another feature not found in other breeds: a short, kinked tail or “screwtail,” said Professor Danika Bannasch, Department of Population Health and Reproduction in the UC Davis School of Veterinary Medicine. These three breeds all lack the vertebrae that make up the tail bone, she said.The researchers sequenced the whole genome — the entire DNA sequence — of 100 dogs, including 10 from screwtail breeds. All the participating dogs were privately owned pets seen at the UC Davis Veterinary Medical Teaching Hospital, whose owners agreed to participate. Graduate students Tamer Mansour and Katherine Lucot, with C. Titus Brown, associate professor at the School of Veterinary Medicine and Genome Center, searched through the DNA sequences to find changes associated with screwtail breeds.From more than 12 million individual differences they were able to identify one mutation, in a gene called DISHEVELLED 2 or DVL2. This variant was found in 100 percent of the bulldogs and French bulldogs sampled, and was very common in Boston terriers.This kind of whole genome comparison is relatively new, Bannasch said.”Normally, we would have first had to identify a region DNA and work from there,” she said. “We could look at breed-specific traits, but not as well as we can now.”Link to Robinow syndromeRelated StoriesFungal infection study identifies specific genetic vulnerability among Hmong peopleNew study identifies eight genetic variants associated with anorexia nervosaDoes genetic testing affect psychosocial health?Professor Henry Ho at the UC Davis School of Medicine studies similar genes in humans. Mutations in the related DVL1 and DVL3 genes are known to cause Robinow syndrome, a rare inherited disorder in humans characterized by strikingly similar anatomical changes — a short, wide “babyface,” short limbs and spinal deformities. In addition, Robinow patients and the screwtail breeds also share other disease traits, such as cleft palate. In both humans and dogs, DVL genes are part of a signaling pathway called WNT involved in development of the skeleton and nervous system, among other things, said Peter Dickinson, professor of surgical and radiological sciences at the School of Veterinary Medicine. By characterizing the screwtail DVL2 protein product, Sara Konopelski, a graduate student the Ho lab, pinpointed a key biochemical step in the WNT pathway that is disrupted by the mutation. This finding further suggests that a common molecular defect is responsible for the distinct appearances of both Robinow patients and screwtail dog breeds.The DVL2 screwtail mutation is so common in these breeds, and so closely tied to the breed appearance, that it would be difficult to remove it by breeding, Dickinson said. Other genes are known to contribute to short, wide “brachycephalic” heads in dogs, and there are likely multiple genes that contribute both to appearance and to chronic health problems in these breeds.Understanding a common mutation in popular dog breeds may, however, give more insight into the rare Robinow syndrome in humans. Only a few hundred cases have been documented since the syndrome was identified in 1969.”It’s a very rare human disease but very common in dogs, so that could be a model for the human syndrome,” Bannasch said.
Children born with low levels of vitamin D had an approximately 60% higher risk of elevated systolic blood pressure between ages 6 and 18; Children who had persistently low levels of vitamin D through early childhood had double the risk of elevated systolic blood pressure between ages 3 and 18. Systolic refers to the first or top number in a blood pressure reading. It indicates how much pressure your blood is exerting against your artery walls when your heart beats. High systolic blood pressure readings increase the risk of cardiovascular disease even when diastolic blood pressure, the second number in a blood pressure reading, is controlled. Currently, there are no recommendations from the American Academy of Pediatrics to screen all pregnant women and young children for vitamin D levels. Our findings raise the possibility that screening and treatment of vitamin D deficiency with supplementation during pregnancy and early childhood might be an effective approach to reduce high blood pressure later in life.”Guoying Wang, M.D., Ph.D., the study’s lead author and an assistant scientist at Johns Hopkins University Bloomberg School of Public Health in Baltimore, Maryland Related StoriesVitamin D supplementation may not reduce the risk of heart diseaseStudy reveals how habitual smoking may contribute to development of hypertensionGenetic variants may be linked with high blood pressure among blacksWang added that what constitutes optimal circulating vitamin D levels during pregnancy and early childhood remains an active research question, and that their study results need to be replicated in other large populations.Vitamin D is needed for the body to absorb calcium for strong bones. It is made by our bodies when we are exposed to sunlight and found in a few foods, such as eggs, salmon and fortified milk products. It is also available as a vitamin supplement.High blood pressure is a leading, preventable cause of cardiovascular disease worldwide. Along with an increase in obesity among children, the prevalence of high blood pressure in children has been on the rise in recent years, especially among African American children. High blood pressure in childhood is an important risk factor for having high blood pressure and developing cardiovascular disease in adulthood. Source:American Heart AssociationJournal reference:Wang, G. et al. (2019) Vitamin D Trajectories From Birth to Early Childhood and Elevated Systolic Blood Pressure During Childhood and Adolescence. Hypertension: Journal of the American Heart Association. doi.org/10.1161/HYPERTENSIONAHA.119.13120. Reviewed by James Ives, M.Psych. (Editor)Jul 1 2019Vitamin D deficiency from birth to early childhood was associated with an increased risk of elevated blood pressure in later childhood and adolescence, according to new research in the American Heart Association journal Hypertension.Researchers followed 775 children from birth to age 18 at the Boston Medical Center. Most lived in a low-income, urban area and 68% of the children were African American. Low vitamin D levels were defined as less than 11 ng/ml (nanograms per millimeter) in cord blood at birth and less than 25 ng/ml in a child’s blood during early childhood.Compared to children who were born with adequate vitamin D levels:
Citation: Lawyer denies tabloid blackmailed Amazon boss Bezos (2019, February 11) retrieved 17 July 2019 from https://phys.org/news/2019-02-lawyer-denies-tabloid-blackmailed-amazon.html © 2019 AFP “It absolutely is not extortion and not blackmail,” Elkan Abramowitz, who represents National Enquirer parent company American Media Inc (AMI)’s chief executive David Pecker, told ABC television’s “This Week.””What happened was the story was given to the National Enquirer by a reliable source that had been given information to the National Enquirer for seven years prior to the story. It was a source that was well known to both Mr Bezos and Miss (Lauren) Sanchez.”Last month, the supermarket tabloid reported that Bezos, 55, had an extramarital affair with a former news anchor, publishing a trove of private text messages. The report appeared days after Bezos and his wife MacKenzie announced their divorce.When asked if the Enquirer’s source was Sanchez’s brother Michael, as reported by some media outlets, Abramowitz declined to confirm.”It was a person that was known to both Bezos and Ms Sanchez,” he said.”I can tell you it’s not Saudi Arabia, it’s not President Trump, it’s not Roger Stone. But I cannot tell you who the source is.” The attorney was responding to Bezos’s stunning claims published on online platform Medium on Thursday.Bezos hinted he may have been targeted by pro-Trump forces in part because of coverage by The Washington Post, which he owns, of the murder of its contributor Jamal Khashoggi, strangled and dismembered by Saudi agents in the kingdom’s Istanbul consulate in October.But Abramowitz insisted that the Enquirer’s exchanges with Bezos, which the billionaire released in his online post, were simply journalistic negotiating practices rather than extortion.”The story was already published… it was part of a legitimate negotiation,” the lawyer said.”I think both Bezos and AMI had interests in resolving their differences. Bezos didn’t want another story written about him or those pictures published, AMI did not want to have the libel against them that this was inspired by the White House, inspired by Saudi Arabia or inspired by The Washington Post.” For Amazon, it’s business as usual despite CEO drama The National Enquirer’s parent company insists it did not try to extort and blackmail Jeff Bezos with compromising pictures A lawyer denied Sunday allegations by Jeff Bezos that the National Enquirer tabloid had tried to extort and blackmail him, insisting that embarrassing photographs were obtained from a “reliable” source. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Indelible mark A group of women at Hajipur in Bihar’s Vaishali district after casting their votes on Monday West Bengal May 06, 2019 SHARE 0 66% voter turnout in third phase for LS polls Our Bureau Violence and heavy polling in West Bengal contrasted sharply with a shockingly low voter turnout of just 3 per cent in the Anantnag seat in Jammu and Kashmir as the fifth phase of polling in the Lok Sabha elections recorded an overall 62.56 per cent voting on Monday. The provisional voting percentage this time was slightly higher than the 61.75 per cent in 2014 in the 51 Lok Sabha seats across seven States.Elsewhere in the Hindi heartland — Uttar Pradesh (14 seats), Bihar (five seats), Madhya Pradesh (seven seats), Rajasthan (12 seats) and Jharkhand (four seats) — electioneering was spiced up by sharp exchanges. Prime Minister Narendra Modi once again attacked “Bofors accused” late Prime Minister Rajiv Gandhi at a public rally in Jharkhand and Union Minister Smriti Irani accused Congress President Rahul Gandhi of “booth capturing” in Amethi.Gathbandhan vs BJPMonday’s polling saw Union Home Minister Rajnath Singh contest from Lucknow, Rahul against Irani in Amethi, Sonia Gandhi from Rae Bareli and former Union Minister Rajiv Pratap Rudy from Saran in Bihar. In the 14 seats across Awadh and the eastern regions of Uttar Pradesh, the Gathbandhan of SP/BSP/RLD is locked in a direct and keen contest with BJP. In 2014, the BJP had bagged 12 of the 14 seats. Polling percentage for these seats was slightly higher at 57.33 per cent, against 56.92 per cent in 2014.The situation was volatile in West Bengal, which recorded a higher voter turnout of 73.97 per cent and much street violence. Violence in West BengalAt least three BJP candidates were attacked and intermittent violence was reported across seven seats — Howrah, Uluberia, Hooghly, Serampore, Arambagh, Barrackpore and Bongaon. The seats comprise a stronghold of the Trinamool Congress, which is locked in a hostile fight with the BJP.In Barrackpore, BJP candidate and local strongman Arjun Singh suffered injuries on his face after an alleged attack by TMC workers. Singh, a TMC dissident miffed at not being given a party ticket, is taking on former Railway Minister and sitting TMC MP Dinesh Trivedi. In Hooghly, BJP candidate Locket Chatterjee was heckled and her car vandalised, allegedly by TMC workers, in the Dhanekhali area. Chatterjee is taking on TMC’s Ratna De Nag. The border seat of Bongaon saw a TMC worker suffer head injuries after motor bike-borne miscreants hurled crude bombs at Himli.In Anantnag, the Lok Sabha seat in J&K where polling is being held in three legs in view of the security threats, a shocking 3 per cent voting was reported with over 25 per cent stations not recording any polling. Polling there ended at 4 pm, two hours before the scheduled time for other seats. The final count of 3 per cent included even migrant votes in six Assembly segments across two districts, Election Commission (EC) officials said.The EC had clubbed many polling stations at one location to ensure minimal dispersion of security forces in Shopian and Pulwama districts, where deserted roads and the heavy presence of armed forces marked polling day.More reports p14 RELATED 62.5% polling in 51 LS seats across seven States as against 61.7% recorded in 2014 SHARE SHARE EMAIL COMMENT Lok Sabha polls 2019: In phase 4, Bengal records highest turnout of 76.4%; overall turnout at 64% national elections Published on Lok Sabha COMMENTS